KAWAI Hideki(Associate Professor)


Specialized field General neuroscience
Neuro/muscular physiology
Classes Bioinformatics Seminar 3
Bioinformatics Seminar 4
Japan Studies Program Enginieering and Natural Sciences
General Topics in Science and Engineering
Project Studies A
Project Studies B
Chemistry A
Biology B
Chemistry Laboratory
Neuroscience 1
Neuroscience 2
Advanced Bioinformation Engineering
Advanced Research in Bioinformation Engineering
Advanced Course of Bioengineering
Advanced Laboratory Course of Bioengineering
Laboratory in Bioinformatics 1
Laboratory in Bioinformatics 2
Research theme Physiology and plasticity in cerebral cortex

Application for coverage

Detail of researcher information

Bioinformatics of Graduate school of engineering

  • Career summary 1989-1992 University of Minnesota, Institute of Technology, Department of Chemistry, B.Chem.
    1993-1998 University of Minnesota Graduate School, Department of Pharmacology, Ph.D.
    1998-2001 University of California, San Diego, Division of Biology, Neurobiology group, Postgraduate Research Biologist
    2001-2003 Brown University, Department of Neuroscience, Postdoctoral Research Associate
    2003-2006 University of California, Irvine, Department of Neurobiology and Behavior, Postgraduate Researcher
    2006-2009 University of California, Irvine, Department of Neurobiology and Behavior, Assistant Project Scientist
    2009-present Soka University, Faculty of Engineering, Department of Bioinformatics, Associate Professor
    Disciplinary Neuroscience: Neurobiology, Neurophysiology, Neuropharmacology
    Research Theme Physiology and Plasticity in Cerebral Cortex

    Our laboratory is interested in cortical formation, neuronal function at synaptic, cellular, and systems levels, and experience-dependent changes in the neural circuit of auditory cortex.

    The cerebral cortex of humans and animals processes sensory information obtained from the five sensory organs and integrates it with other information for perception and cognition. Neural circuits of cerebral cortex, which makes such higher-order information processing possible, are formed during development based on genetic programs but at the same time shaped by experiences. Our laboratory aims to understand how neocortex, auditory cortex in particular, forms normally and how its neural circuit formation is influenced by experiences such as sensory deprivation and injuries. We hope to understand fundamental principles and mechanisms underlying neural reorganization so as to contribute to the treatment of psychiatric and cognitive disorders. We utilize a variety of experimental techniques, including in vitro and in vivo electrophysiology, confocal microscopy, imaging, histochemistry, biochemistry, and molecular biology.

    Our current research topics include:
    • Cholinergic, nicotinic in particular, regulation of neuronal processing in auditory thalamocortical system
    • Cross-modal interaction and plasticity in auditory cortex
    • Formation of auditory thalamocortical system
    • Proliferation and differentiation of neural stem cells in cerebral cortex
    acetylcholine, nicotine, synapse, neuronal excitability, transcription, corticogenesis, visual deprivation, ischemia
    Publications Fukuzaki Y, Shin H., Kawai H. D., Yamanoha B., Kogure S. (2015) 532 nm low-power laser irradiation facilitates the migration of GABAergic neural stem/progenitor cells in mouse neocortex. PLOS ONE, 10(4):e0123833

    Kumazaki K, Mieda T, Kogure S, Kawai H. (2013) Layer-specific modulation of neuronal excitability by 660-nm laser irradiation in mouse neocortex. Lasers in Med Sci PMID: 24232863

    Kawai, H.D., La, M., Kang H.-A., Hashimoto, Y., Liang, K., Lazar, R., Metherate, R. (2013) Convergence of nicotine-induced and auditory-evoked neural activity activated ERK in auditory cortex. Synapse, 67(8):455-68

    Metherate, R., Intskirveli, I,, Kawai, H.D. (2012) Nicotinic filtering of sensory processing in auditory cortex. Front Behav Neurosci. 2012;6:44.

    Bieszczad, K. M., Kant, R., Constantinescu, C. C., Pandey, S. K., Kawai, H. D., Metherate, R., Weinberger, N. M., Mukherjee, J. (2012) Nicotinic acetylcholine receptors in rat forebrain that bind (18) F-nifene: Relating PET imaging, autoradiography and behavior. Synapse 66(5):418-34

    Kawai, H.D., Kang, H.-A., Metherate, R. (2011) Heightened nicotinic regulation of auditory cortex during adolescence. J. Neurosci. 31(40), 14367-14377

    Kawai, H., Raftery, M. A. (2010) Kinetics of agonist-induced intrinsic fluorescence changes in the Torpedo acetylcholine receptor. J. Biochem. 147(5), 743-9

    Deshpande, A., Kawai, H., Metherate, R., Glabe, C. G., Busciglio J, (2009) A role for synaptic zinc in activity-dependent Aβ oligomer formation and accumulation at excitatory synapses. J. Neurosci.29(13), 4004-4015.

    Kawai, H., Dunn, S. M. J., Raftery, M. A. (2008) Epibatidine binds to four sites on the Torpedo nicotinic acetylcholine receptor. Biochem. Biophys. Res. Commun. 366, 834-839.

    Kawai, H., Lazar, R., Metherate, R. (2007) Nicotinic control of axon excitability regulates thalamocortical transmission. Nature Neurosci. 10, 1168-1175.

    Carter, C.R.J., Cao, L., Kawai, H., Smith, P.A., Dryden, W.F., Raftery, M.A., Dunn, S.M.J. (2007) Chain length dependence of the interactions of bisquaternary ligands with the Torpedo nicotinic acetylcholine receptor. Biochem. Pharmacol. 73(3), 417-426.

    Metherate, R., Kaur, S., Kawai, H., Lazar, R., Liang, K., Rose, H.J. (2005) Spectral integration in auditory cortex: mechanisms and modulation. Hear Res. 206(1-2), 146-58.

    Gabel, L.A., Won, S., Kawai, H., McKinney, M., Tartakoff, A.M., Fallon, J.R. (2004) Visual experience regulates transient expression and dendritic localization of Fragile X Mental Retardation Protein. J. Neurosci. 24(47), 10579-83.

    Kawai, H., Zago, W., Berg, D. K. (2002) Nicotinic α7 receptor clusters on hippocampal GABAergic neurons: Regulation by synaptic activity and neurotrophins. J. Neurosci. 22(18), 7903-7912.

    Kawai, H., Berg, D. K. (2001) Nicotinic acetylcholine receptors containing α7 subunits on
    rat cortical neurons do not undergo long-lasting inactivation even when up-regulated by
    chronic nicotine exposure. J. Neurochem. 78(6), 1367-1378.

    Liu, Q.-S., Kawai, H., Berg, D. K. (2001) β-Amyloid peptide blocks the response of α7-
    containing nicotinic receptors on hippocampal neurons. Proc. Natl. Acad. Sci., U.S.A. 98(8), 4734-4739.

    Kawai, H., Cao, L., Dryden, W. F., Dunn, S. M. J., Raftery, M. A. (2000) The interaction ofa novel semi-rigid agonist with Torpedo acetylcholine receptor. Biochemistry 39, 3867-3876.

    Kawai, H., Carlson, B. J., Okita, D. K., Raftery, M. A. (1999) Eserine and other tertiary amine interactions with Torpedo acetylcholine receptor post-synaptic membrane vesicles. Biochemistry 38, 134-141.
    Membership of Academic Societies Society for Neuroscience, American Physiological Society, Molecular and Cellular Cognition Society, Association for Research in Otolaryngology, Japan Neuroscience Society