FUJIWARA Kazuo(Associate Professor)


Specialized field Biological/living body informatics
Structural biochemistry
Classes Bioinformatics Seminar 3
Bioinformatics Seminar 4
Seminar in Programming 1
Seminar in Programming 2
Project Studies A
Project Studies B
Computer Programming 1
Case Study 1
Case Study 2
Physical Chemistry Laboratory
Advanced Biopolymer Science
Advanced Course of Bioengineering
Advanced Laboratory Course of Bioengineering
Laboratory in Bioinformatics 1
Laboratory in Bioinformatics 2
Research theme Protein Engineering

Application for coverage

Detail of researcher information

Bioinformatics of Graduate school of engineering

  • Research Interests - Statistical studies on the relationship between amino acid sequence and structure of protein
    - Experimental studies on the protein folding mechanism
    Major Publications 1. Sato D, Takebe S, Kurobe A, Ohtomo H, Fujiwara K, Ikeguchi M.
    Electrostatic Repulsion during Ferritin Assembly and Its Screening by Ions.
    Biochemistry. 2016 Jan 26;55(3):482-8.
    2. Sato D, Ohtomo H, Yamada Y, Hikima T, Kurobe A, Fujiwara K, Ikeguchi M.
    Ferritin Assembly Revisited: A Time-Resolved Small-Angle X-ray Scattering Study.
    Biochemistry. 2016 Jan 19;55(2):287-93.
    3. Fujiwara K, Ebisawa S, Watanabe Y, Fujiwara H, Ikeguchi M.
    The origin of β-strand bending in globular proteins.
    BMC Struct Biol. 2015 Oct 22;15:21.
    4. Ohtomo H, Ohtomo M, Sato D, Kurobe A, Sunato A, Matsumura Y, Kihara H, Fujiwara K, Ikeguchi M.
    A Physicochemical and Mutational Analysis of Intersubunit Interactions of Escherichia coli Ferritin A.
    Biochemistry. 2015 Oct 13;54(40):6243-51.
    5. Okabe T, Miyajima T, Nakagawa K, Tsukamoto S, Fujiwara K, Ikeguchi M.
    Effect of non-native helix destabilization on the folding of equine β-lactoglobulin.
    J Biochem. 2014 Nov;156(5):291-7.
    6. Okabe T, Tsukamoto S, Fujiwara K, Shibayama N, Ikeguchi M.
    Delineation of solution burst-phase protein folding events by encapsulating the proteins in silica gels.
    Biochemistry. 2014 Jun 17;53(23):3858-66.
    7. Fujiwara K, Ebisawa S, Watanabe Y, Toda H, Ikeguchi M.
    Local sequence of protein β-strands influences twist and bend angles.
    Proteins. 2014 Jul;82(7):1484-93.
    8. Nakagawa K, Yamada Y, Matsumura Y, Tsukamoto S, Yamamoto-Ohtomo M, Ohtomo H, Okabe T, Fujiwara K, and Ikeguchi M.
    Relationship between chain collapse and secondary structure formation in a partially folded protein.
    Biopolymers. 2014 Jun;101(6):651-8.
    9. Fujiwara K, Toda H, Ikeguchi M.
    Dependence of alpha-helical and beta-sheet amino acid propensities on the overall protein fold type.
    BMC Struct Biol. 2012 Aug 2;12:18.
    10. Ohtomo H, Fujiwara K, Ikeguchi M.
    Important Role of Methionine 145 in Dimerization of Bovine β-Lactoglobulin.
    J Biochem. 2012 Mar;151(3):329-34.
    11. Yamamoto M, Nakagawa K, Fujiwara K, Shimizu A, Ikeguchi M, Ikeguchi M.
    A native disulfide stabilizes non-native helical structures in partially folded states of equine β-lactoglobulin.
    Biochemistry. 2011 Dec 13;50(49):10590-7.
    12. Tsukamoto S, Fujiwara K, Ikeguchi M.
    Fatty acids bound to recombinant tear lipocalin and their role in structural stabilization.
    J Biochem. 2009 Sep;146(3):343-50.
    13. Tsukamoto S, Yamashita T, Yamada Y, Fujiwara K, Maki K, Kuwajima K, Matsumura Y, Kihara H, Tsuge H, Ikeguchi M.
    Non-native alpha-helix formation is not necessary for folding of lipocalin: Comparison of burst-phase folding between tear lipocalin and beta-lactoglobulin. Proteins. 2009 Jul;76(1):226-36.
    14. Fujiwara K, Ikeguchi M.
    OLIGAMI: OLIGomer Architecture and Molecular Interface.
    The Open Bioinformatics Journal, 2008, 2, 50-53.
    15. Nakagawa K, Yamada Y, Fujiwara K, Ikeguchi M.
    Interactions Responsible for Secondary Structure Formation during Folding of Equine beta-Lactoglobulin.
    J Mol Biol. 2007 April 6;367(4):1205-1214.
    16. Nakagawa K, Tokushima A, Fujiwara K, Ikeguchi M.
    Proline Scanning Mutagenesis Reveals Non-Native Fold in the Molten Globule State of Equine beta-Lactoglobulin.
    Biochemistry. 2006 Dec 26;45(51):15468-15473.
    17. Yamada Y, Nakagawa K, Yajima T, Saito K, Tokushima A, Fujiwara K, Ikeguchi M.
    Structural and thermodynamic consequences of removal of a conserved disulfide bond from equine beta-lactoglobulin.
    Proteins. 2006 May 15;63(3):595-602.
    18. Yamada Y, Yajima T, Fujiwara K, Arai M, Ito K, Shimizu A, Kihara H, Kuwajima K, Amemiya Y, Ikeguchi M.
    Helical and Expanded Conformation of Equine beta-Lactoglobulin in the Cold-denatured State.
    J Mol Biol. 2005 Jul 8;350(2):338-48.
    19. Fujiwara K, Ikeguchi M, Sugai S.
    A partially unfolded state of equine beta-lactoglobulin at pH 8.7.
    J Protein Chem. 2001 Feb;20(2):131-7.
    20. Fujiwara K, Arai M, Shimizu A, Ikeguchi M, Kuwajima K, Sugai S.
    Folding-unfolding equilibrium and kinetics of equine beta-lactoglobulin: equivalence between the equilibrium molten globule state and a burst-phase folding intermediate.
    Biochemistry. 1999 Apr 6;38(14):4455-63.
    Membership of Academic Societies - Biophysical Society of Japan
    - Protein Science Society of Japan