NAKAJIMA Kazuyuki(Professor)


Specialized field Neurochemistry/neuropharmacology
Classes Genom and account of the life
Bioinformatics Seminar 3
Bioinformatics Seminar 4
Biology A
Biology B
Cell Biology
Current Topics in Biological Information Systems
Advanced Study of Biological Information Systems
Current Topics in Ecological Study
Advanced Course of Bioengineering
Advanced Laboratory Course of Bioengineering
Laboratory in Bioinformatics 1
Laboratory in Bioinformatics 2
Research theme Analysis of glial function in the nervous system

Application for coverage

Detail of researcher information

Bioinformatics of Graduate school of engineering

  • Discipline Neurochemistry
    Research Theme Role of glial cells in the nervous system
    Injury and regeneration of nervous system
    Publications (selected) (1) Nakajima K, Reddington M, Kohsaka S. and Kreutzberg GW.
    Induction of urokinase-type plasminogen activator in rat facial nucleus by axotomy of the facial nerve.
    J. Neurochem. 66 (1996) 2500-2505.

    (2) Nakajima K, Kikuchi Y, Ikoma E, Honda S, Ishikawa M. Liu Y.and Kohsaka S.
    Neurotrophins regulate the function of cultured microglia.
    Glia 24 (1998) 272-289.

    (3) Nakajima K, Honda S, Tohyama Y, Imai Y, Kohsaka S, KuriharaT.
    Neurotrophin secretion from cultured microglia.
    J. Neurosci. Res. 65 (2001) 322-331.

    (4) Nakajima K, Kohsaka S.
    Neuroprotective roles of microglia in the central nervous system.
    In: Microglia in the regenerating and degenerating central nervous system (WJ Streit, ed), pp188-208,
    Springer-Verlag, New York, 2001

    (5) Nakajima K, Tohyama Y, Kohsaka S, Kurihara T.
    Ceramide activates microglia to enhance the production/secretion of brain-derived neurotrophic factor (BDNF)
    without induction of deleteriousfactors in vitro.
    J. Neurochem. 80 (2002) 697-705.

    (6) Nakajima K, Kurihara T, Kohsaka S.
    Molecular mechanisms determining opposed functional states of microglia.
    Current Neuropharmacology, 1 (2003) 245-265.

    (7) Nakajima K, Kohsaka S.
    Microglia: Neuroprotective and neurotrophic cells in the central nervous system.
    Current Drugs-Cardiovascular & Haematological Disorders, 4 (2004) 65-84.

    (8) Nakajima K, Kohsaka S.
    Response of microglia to brain injury.
    In: neuroglia second edition (H Kettenmann and BR Ransom, ed), pp 443-453,
    Oxford University Press, New York, 2005.

    (9) Nakajima K, Graeber MB, Sonoda M, Tohyama Y, Kohsaka S, Kurihara T.
    In vitro proliferation of axotomized rat facial nucleus-derived activated microglia in an autocrine fashion.
    J Neurosci Res. 84 (2006) 348-359.

    (10) Matsushita Y, Nakajima K, Tohyama Y, Kurihara T, Kohsaka S.
    Activation of microglia by endotoxin suppresses the secretion of glial cell line-derived neurotrophic factor (GDNF)
    through the action of protein kinase Ca (PKCa) and mitogen-activated protein kinases (MAPKs).
    J Neurosci Res. 86 (2008) 1959-1971.

    (11) Yamamoto S, Nakajima K, Kohsaka S.
    Macrophage-colony stimulating factor (M-CSF) as an inducer of microglial proliferation in axotomized rat facial
    J Neurochem. 115 (2010) 1057-1067.

    (12) Yoshino Y, Yamamoto S, Kohsaka S, Oshiro S, Nakajima K.
    Superoxide anion contribute to the induction of tumor necrosis factor alpha (TNF?) through activation of the MKK3/6-p38
    MAPK cascade in rat microglia.
    Brain Res. 1422 (2011) 1-12.

    (13) Nakajima K, Kohsaka S.
    Interaction of microglia with neurons and astrocytes under lesioned neuronal conditions.
    In: neuroglia third edition (H Kettenmann and BR Ransom, ed), pp 677-686,
    Oxford University Press, New York, 2012.

    (14) Yamamoto S, Kohsaka S, Nakajima K.
    Role of cell cycle-associated proteins in microglial proliferation in the axotomized rat facial nucleus.
    Glia. 60 (2012) 570-581.

    (15) Ichimiya T, Honda Y, Yamamoto S, Kikuchi R, Kohsaka S, Nakajima K.
    Functional down-regulation of axotomized rat facial motoneurons.
    Brain Res. 1507 (2013) 35-44.

    (16) Takezawa Y, Kohsaka S, Nakajima K.
    Transient down-regulation and restoration of glycogen synthase levels in axotomized rat facial motoneurons.
    Brain Res. 1586 (2014) 34-45.

    (17) Takezawa Y, Baba O, Kohsaka S, Nakajima K.
    Accumulation of glycogen in axotomized adult rat facial motoneurons.
    J Neurosci Res. (2015) 93(6):913-921. doi: 10.1002/jnr.23546.

    (18) Sudo K,Takezawa Y, Kohsaka S,Nakajima K.
    Involvement of nitric oxide in the induction of interleukin-1 beta in microglia.
    Brain Res. 1625 (2015)121-134.
    Membership of Academic Societies The Japanese Society for Neurochemistry
    The Japanese Society for Neuroscience
    The Japanese Biochemical Society
    The Japanese Society for Bioscience, Biotechnology and Biochemistry
    The society for Neuroscience